Vital Health News

Bovine Colostrum & Immune Modulation

Clinically Proven Immunomodulatory and Anti-inflammatory Effect of PRPs in Oral Spray Form


Colostrum, nature's first food, contains an amazing variety of immune factors, growth factors and nutrients that help the newborn get a healthy start in life. What science has also discovered is that the ingredients in colostrum are also good for grownups and children. It can help heal stomach and intestinal linings damaged by pain medication, alcohol and soft drink consumption, poor diet, stress or environmental toxins. It can help keep our immune system running at optimal levels, which is especially important in today's stressful world with new drug-resistant diseases appearing and a worsening environment. For example, a recent Italian study showed that supplementation with whole colostrum was more than three times as effective as immunization in preventing the flu in both normal healthy subjects and high risk cardiovascular subjects.

A new immunomodulatory product which concentrates the essence of colostrum's immune factors into an easy-to-take spray is available to help balance your immune system so that it functions at optimal levels to protect you and your loved ones. The essence of this exciting new product is PRPs (Proline-Rich Polypeptides). PRPs are peptides – short strings of amino acids (the building blocks of proteins) – that function as intercellular signaling molecules. The PRPs in colostrum are specifically designed to modulate the activity of the immune system, stimulating its activity when needed to fight off an infection or quelling its activity to prevent tissue damage once the infection has been defeated.

PRPs in colostrum consist of a number of different peptides which can be separated by gel chromatography into three distinct classes. One of these, PRP3, is the most immunologically active. Modern protein fractionation methods allow this fraction to be isolated as the main ingredient, providing the maximum immunologic punch at a fraction of the cost of whole colostrum. PRPs act as a hormone in the thymus gland by stimulating thymocytes (lymphocytes that originate in the thymus gland) to differentiate and become activated as either helper or suppressor T-cells. What is unique about the action of PRPs is that this effect is reversible. Helper T-cells present foreign antigen (such as a protein from a virus or bacteria) to B-cells, lymphocytes which originate in the bone marrow and which produce antibodies that are specific to the antigens presented to them by the helper T-cells. Helper T-cells also help produce memory T-cells, lymphocytes that retain the memory of the antigen to shorten response time in case of reinfection.

Suppressor T-cells, on the other hand, deactivate other lymphocytes to "turn off" the immune response after an infection is under control. This is important because if the response is not turned off, normal tissue can be damaged. Autoimmune diseases, such as rheumatoid arthritis, lupus, or type 1 diabetes, are characterized by overactive immune systems that attack the tissues of the body. PRPs have shown promise against autoimmune diseases in preliminary trials.. PRPs are also potent stimulators of other immune cells in response to an infection. They induce the growth and differentiation of B-cells, increase the permeability of the blood vessels in the skin to allow hunter/killer cells to move into the tissues, and induce leukocyte (white blood cell) proliferation. PRPs also induce the differentiation and maturation of monocytes and macrophages, cells which penetrate the connective tissue outside the blood vessels in search of pathogens .

PRPs have been shown to be potent stimulators of natural killer (NK) cell activity. Dr. Daryl See, MD, Director of the Bioassay Laboratory at the Institute of Longevity Medicine, conducted a comparative study of 196 dietary supplements which claimed immune system enhancement, broad-spectrum antimicrobial activity and antioxidant action. Bovine colostrum was shown to promote significant NK cytotoxicity. Later studies by Dr. See showed that transfer factor (PRPs) increased NK cell cytotoxicity by up to 400%. Among other natural products which increase NK cell cytotoxicity, none exceeded a 50% increase. Another study by Dr. See showed that a combination of nutraceutical products, including transfer factor (PRPs) increased the cytotoxic activity of NK cells in patients with late-stage cancer .

The mechanism through which PRPs act includes the stimulation of immune cells to produce various pro- and anti-inflammatory cytokines. Cytokines are also small peptides and proteins that control the immune response. PRPs can stimulate the production of tumor necrosis factor-alpha (TNF-α), which is the cytokine that controls the entire inflammatory cascade of cytokines that are secreted when the immune system is mobilized to fight infection, and gamma interferon (INF-γ), another major cytokine that interferes with the ability of pathogens, especially viruses, to replicate. PRPs have been shown to stimulate the production of INF-γ in white blood cells , peritoneal cells, and cells of the placenta and amniotic membrane. The so-called immune cascade is a complex series of chemical events that mobilize immune cells to move to the site of the infection (such as a wound) and attack any pathogens they find.

PRPs also have the ability to stimulate the production of both pro- and anti-inflammatory cytokines in peripheral blood cells – the very cells that would be actively engaged in fighting an infection. Again, this reflects the ability of PRPs to respond to the immunological needs of the body by modulating the immune response. An example of how fine it can tune the system was demonstrated in an experiment where mice were exposed to Herpes simplex virus (HSV). When exposed, the mice produced large quantities of INF-γ, IL-2, a pro-inflammatory cytokine that is produced in response to an infection, and small amounts of IL-10, an anti-inflammatory cytokine. However, if the mice were first exposed to transfer factor (another name for PRPs), the mice responded to HSV by producing large amounts of INF-γ but no IL-2 . In blood cultures, PRP stimulates the production of INF-α, INF-γ, IL-6 (a pro-inflammatory cytokine) and IL-10 .

PRPs provide immunity to a number of viruses, including HSV, Epstein-Barr virus (a type of herpes virus that causes infectious mononucleosis), HIV, measles, and others. It also has antiviral activity against several viruses, Epstein-Barr and Human Herpes Virus-6 (HHV-6) known to be associated with autoimmune diseases.

The use of PRPs in clinical situations to treat dangerous infectious diseases is just being explored. PRPs have been used with AIDS patients in various African countries. Through its immunomodulatory effect, PRP oral spray products boosted T-cells (CD4+) levels to normal or near-normal levels in nearly all patients studied associated with a complete remission of AIDS symptoms, such as nausea, vomiting, diarrhea, and so forth. Weight gains of up to 5% were also noted. In fact, those taking PRPs performed much better in terms of quality of life than those on antiretroviral drugs.

The potential for clinical use of PRPs is exciting. Bird flu, for example, kills patients by eliciting a so-called "cytokine storm" caused by dysregulation of normal cytokine regulation by the virus that actually kills the victim by drowning in their own fluids. PRPs could help restore cytokine regulation and restore homeostasis.

PRPs may also prove useful in the treatment of allergies and asthma. In a recent Russian study, guinea pigs were given an injection of ovalbumin which causes them to develop bronchial spasms which often prove fatal. When PRPs were administered given to the guinea pigs, fewer died, and the bronchial spasms in the others were less severe and of significantly shorter duration.

PRPs are not species specific, meaning that PRPs from cow's colostrum is just as effective in humans as PRPs from human colostrum . PRPs are concentrated out of the highest quality bovine colostrum that is collected fresh year-round from cows living in the Southwestern United States and processed in the only processing plant using state-of-the-art equipment. It is safe for all ages, including children. It is packaged as a convenient, easy to use oral spray. Two or three sprays two to four times a day is the normal dose.

Colostrum's PRPs can help you stay healthy naturally by modulating your immune system to perform at its best.

PDF article with scientific references available HERE.

Sovereign Health Initiative

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The Sovereign Health Initiative is committed to the belief that each person holds sovereignty over his or her body. We further support the principle that in order to take ownership of one’s health, it is necessary to make informed decisions through self-education. To this end, it is our aim to offer critical information to educate the public on how to live a lifetime in optimal health.

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