Vital Health News

Bovine Colostrum and Immune Modulation: Managing Viral Threats with PRPs

by Douglas A. Wyatt, Townsend Letter, January 2015

Immune modulation is the most significant factor in whether a patient recovers from a life-threatening viral infection. Simply put, an individual’s immune system, when functionally optimally, has the ability to fight off infection(s). From influenza to HIV/AIDS to hemorrhagic fevers, the active components in bovine colostrum possess real promise in the fight against these and other viral infections. Colostrum’s antiviral activity is due to its antibodies, lactoferrin, lactoperoxidase, lysozyme, and other immune factors which bind to pathogens and destroy their cell membranes or compete for binding sites on the intestinal wall. Even more significant are the Proline-rich polypeptides (PRPs) which play a major role by modulating the activity of the immune system. PRPs stimulate immune system activity when needed to fight off an infection or quell its activity to prevent tissue damage once the infection has been defeated.


Lactoferrin Peptides

Lactoferrin is an iron-binding protein with many functions and is part of the body's innate, non-specific immune system that helps the body combat pathogens of all varieties. Lactoferrin’s primary mechanism is blocking the entry of viruses into target cells by competing for binding sites on the cells or by binding to viral proteins to inactivate them so that macrophages and other scavenger cells can dispose of them. It also acts as an immune modulator to help stimulate the immune system to respond to infections.


Proline-Rich Polypeptides (PRPs)

PRPs are small chains of ten amino acids or fewer, notably proline, that enhance the ability of thymus gland to release factors that help regulate immune functions in the body. Specifically, certain T-cells, called TH1 helper cells, are antagonist to the activity of TH2 helper cells that promote certain functions of B lymphocytes. PRPs can induce a shift from a predominantly humeral immune response to a more protective cellular response described as a "TH2 to TH1 shift". In doing so, the immune system becomes more effective in fighting viral infections. Whole bovine colostrum and specifically PRPs have been shown to have anti-viral activity against: Adenovirus, Alphavirus, Dengue virus, Echovirus, Epstein-Barr virus, Enterovirus 71, Hantavirus, Hepatitis C virus, Herpes viruses, HIV-1, Human Papilloma virus, Influenza, Japanese encephalithis, Measles, Poliovirus, Respiratory syncytial virus, Rotavirus, St. Louis virus, West Nile virus, and Yellow fever virus.

PRPs can be classified into three distinct classes, of which the PRP-2s and PRP-3s are the most immunologically active. They induce the growth and differentiation of B-cells; increase the permeability of the blood vessels in the skin to allow killer cells to move into the tissues; and induce leukocyte proliferation. PRPs also induce the differentiation and maturation of monocytes and macrophages, cells which penetrate the connective tissue outside the blood vessels in search of pathogens. The mechanism by which PRPs act includes the stimulation of immune cells to produce various pro- and anti-inflammatory cytokines which control the immune response. PRPs can stimulate the production of tumor necrosis factor-alpha (TNF-α), which is the cytokine that controls the entire inflammatory cascade of cytokines that are secreted when the immune system is mobilized to fight infection, and gamma interferon (INF-γ), another major cytokine that interferes with the ability of pathogens, especially viruses, to replicate. PRPs have been shown to stimulate the production of INF-γ in white blood cells, peritoneal cells, and cells of the placenta and amniotic membrane. The so-called immune cascade is a complex series of chemical events that mobilize immune cells to move to the site of the infection and attack any pathogens they encounter.


Clinical Studies of Colostrum and Colostrum-Derived PRPs

Clinical application using PRPs to treat infectious diseases has been limited, yet data from the trials with HIV/AIDS patients in Africa and influenza patients in Italy has been extraordinary. Several independent trials utilizing a concentrated oral PRP and lactoferrin mouth spray (Viralox®) tested the effectiveness in HIV/AIDS patients, particularly people living in areas of the world where anti-retroviral treatments are unavailable. Preliminary phase I studies at the Infectious Disease Clinic in Dayton, Ohio showed promise in increasing or normalizing CD4+ T-cell counts. Phase II studies were conducted in Kenya and Nigeria with larger patient groups. Patients took three sprays (2 ml total) every four hours. Results showed increases in CD4+ T-cell counts to normal or near normal levels; reduction in viral loads; and the remission of HIV/AIDS related physical symptoms (nausea, vomiting, and diarrhea) in most patients. Within days, there was a reduction of clinical symptoms, and within six to twelve weeks of treatment, there were significant weight gains (up to 5%). Patients taking Viralox® performed much better in terms of quality of life than patients on antiretroviral drugs. Phase III studies are ongoing in India.

The HIV/AIDS studies suggest that even in the “worst of the worst” viral infections, PRPs could return the human immune system to normal functioning, such that it is able to successfully fight off viral invaders. The ability of PRPs to stimulate an otherwise insufficient immune response by inducing the production of new helper T-cells appears to enable an HIV/AIDS patient’s immune system to recover sufficiently so that it can fight HIV on its own. Researchers concluded that an oral PRP spray treatment could either be an alternative treatment or adjunct treatment in HIV/AIDS patients. The benefits of PRPs in oral spray form include convenience, easy administration, low cost, no side effects, and safety for all ages.

An epidemiological study in San Valentino, Italy investigated the effectiveness of 2 months of oral whole colostrum supplementation on the incidence of seasonal influenza in both healthy and high-risk cardiovascular individuals. After three months of follow-up, the incidence of complications and hospital admission from influenza was higher in the group that received only a vaccination compared with the groups that received either colostrum or colostrum plus vaccination. Individuals who did not receive colostrum also experienced three times more days of flu symptoms. Researchers concluded that colostrum, both in healthy subjects and high-risk cardiovascular patients, provided at least three times more protection against the flu than vaccination. A later study evaluated the efficacy of oral colostrum and a probiotic supplement in the prevention of influenza compared to vaccination. Similar results were obtained. Individuals receiving either colostrum plus probiotics or colostrum plus probiotics plus vaccination fared better than those receiving vaccination alone or no treatment at all. They experienced fewer incidences of flu and fewer flu days. Those receiving a vaccination had twice as many episodes of flu than those receiving the colostrum and probiotic supplement.

The influenza studies suggest that whole colostrum has activity against the numerous viruses that cause seasonal influenza. This is good news for individuals who oppose vaccination. Another added benefit is that supplementing with whole colostrum is cost-effective, particularly when considering the financial cost of decreased workplace productivity and lost wages.


Use of Colostrum and Colostrum-Derived PRPs in Medical Practice

PRPs are being heralded as the most exciting discovery in immunology to come along in decades. Taking PRPs is like downloading immune information directly from the cow's immune system to ours. It gives our immune army generals' classified information about the invading enemy. It's completely different from any mineral, vitamin or herb; it's immune intelligence. As a physician, it is easy to tell my colleagues about this product that is scientifically based and so effective. There are hundreds of scientific studies backing up the scores of personal experiences about PRPs. I believe PRPs are, without a doubt, the greatest discovery of the century in supporting and modulating the immune system. I believe a strengthened immune system will be the primary way to stay well in the future. This nutrient can affect the immune system like nothing else can”. ~Robert Robertson, M.D.

“The use of a general PRPs preparation is well justified for preventative use. Much of what we have seen in the cases of AIDS and even the flu is that it is not the primary infection that kills, but rather the secondary, opportunistic infections that destroy the weakened individual”. ~William Hennen, M.D.


Protecting Healthcare Providers

By virtue of their professions, healthcare providers are bombarded by infectious agents, and among the many pathogens that cause pose the biggest threat to well-being, viruses are pre-eminent. Antibiotics and anti-parasitics are effective against their respective pathogens, but most viruses have no known treatment, except for allowing the human body to fight them off. Compounding the problem is that many healthcare providers come to work when they are ill, despite knowing the well-established link between sick healthcare workers and the patients they care for. As many as 80% of physicians and 70% of medical residents report going to work ill. Additionally, in the emerging Ebola crisis, it appears that the immune system is no match for the virus. Ebola is a high mortality disease depending on where a patient lives, according to the World Health Organization. In the absence of a widely available, or proven Ebola vaccine, bovine colostrum with liposomal delivery and a concentrated PRP spray are the best defense to stay healthy naturally, for who will take care of patients if healthcare providers are too ill themselves?



Living in today's world requires a strong immune system. In the third millennium, medicine is confronted by new and more virulent pathogens which have either adapted to resist our current drugs or no vaccine exists. Stress, poor nutrition, unhealthy behaviors, and increasing levels of pollution and toxins in the environment weaken the immune system, thereby making humans less effective to defend against them. When the immune system becomes unbalanced, infection and disease get the green light. On the other hand, a healthy, balanced immune system provides the best prophylaxis against illness. Bovine colostrum and the proline-rich polypeptides derived from it are essential to good health in today’s world. PRPs are an alternative to conventional pharmaceutical drug-based medicine and provide hope in the face of conditions that are either untreatable or difficult to treat.


PDF article with scientific references available HERE.

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The Sovereign Health Initiative is committed to the belief that each person holds sovereignty over his or her body. We further support the principle that in order to take ownership of one’s health, it is necessary to make informed decisions through self-education. To this end, it is our aim to offer critical information to educate the public on how to live a lifetime in optimal health.

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