Colostrum Research

Anti-Inflammatory Properties


Goldman AS, Goldblum RM, Hanson LA.  Anti-inflammatory properties in human milk.  Acta Paediatrica Scandinavica 75(5):689-695 (1986).  The major anti-inflammatory components found in human milk (and bovine colostrum) include anti-proteases, lactoferrin, lysozyme, secretory IgA, and a number of antioxidants, including cysteine, ascorbate, alpha-tocopherol and beta-carotene.

PubMed Reference    PMID:2181825

Hanson LA, Mattsby-Baltzer I, Engberg I, Roseanu A, Elverfors J, Motas C. Anti-inflammatory capacities of human milk: lactoferrin and secretory IgA inhibit endotoxin-induced cytokine release. Advances in Experimental Medicine and Biology 371A:669-672 (1995).  Lactoferrin and sIgA [both found in colostrum] inhibit pro-inflammatory cytokines.

PubMed Reference    PMID:8526014

Hayashida K, Kaneko T, Takeuchi T, Shimizu H, Ando K, Harada E. Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis.  Journal of Veterinary Medical Science 66(2):149-152 (2004). Bovine lactoferrin inibited the development of arthritis in a rat experimental system by suppressing TNF-alpha (pro-inflammatory cytokine) and increasing IL-10 (anti-inflammatory cytokine) production.

PubMed Reference    PMID:15031542

Murphey DK, Buescher ES. Human colostrum has anti-inflammatory activity in a rat subcutaneous air pouch model of inflammation. Pediatric Research 34(2):208-212 (1993). In an experimental system in rats, colostrum demonstrated anti-inflammatory effect on wounds by decreasing the numbers of polymorphonuclear leukocytes (white blood cells) in the wound area.

PubMed Reference    PMID:8233726

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